![]() ![]() ![]() The objectives of this study were to optimize fabrication parameters of electrospun nanofibrous membranes from biodegradable PCL and collagen-blended nanofibrous membranes to combine mechanical integrity and spinnability of PCL with high biocompatibility of collagen, and to examine keratinocyte attachment, morphology, proliferation, and cell-matrix interactions. The large surface area of the polymer nanofibers with specific modifications facilitates cell adhesion and control of their cellular functions. Several synthetic polymers such as polycaprolactone (PCL) are generally electrospun for tissue engineering applications because of their remarkable mechanical stability and slow degradation rates. A novel cost-effective electrospun nanofibrous membrane is established for wound dressing and allogeneic cultured epidermal substitute through the cultivation of human dermal keratinocytes for skin defects. Collagen nanofiber production utilizes hexafluoro propanol (HFP) as a solvent for electrospinning. ![]() Electrospinning, a well-established technique for nanofiber production has also been extended for producing nanofibrous structures of natural materials that mimic natural extracellular matrix of mammalian tissues. Fabrication of nanofibrous biomaterials based on natural materials through various techniques is a popular research topic, particularly for biomedical applications. ![]()
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